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EARLIER investigations of the action of insulin on cold-blooded vertebrates have shown that, although large doses usually lead to the appearance of typical convulsions, there is often a long latent period (1–2 days at room temperature) during which there are no visible symptoms^1–3. In experiments performed in March and May the action of insulin on the blood-sugar level of the frog was followed, at intervals, from the time of injection to the development of convulsions. The frogs were kept at room temperature (17°–20° C.) and were injected with four units of insulin (Wellcome 40) in the dorsal lymph sac. The sugar content of the blood was determined by a modification of the method described by King⁴ for obtaining “true sugar” values, which are 15–20 mgm./ ml. lower than those previously recorded for the frog⁵.

1. 1

   Huxley, J. S., and Fulton, J. F., Nature, , ().

   ADSCASArticle Google Scholar

2. 2

   Olmsted, J. M. D., Amer. J. Physiol., 69, ().

   CAS Google Scholar

3. 3

   Gray, I. E., and Hall, F. G., Biol. Bull., 58, ().

   CASArticle Google Scholar

4. 4

   King, E. J., “Micro-analysis in Medical Biochemistry” (J. and A. Churchill, London, ).

   Google Scholar

5. 5

   Smith, C. L., J. Exp. Biol., 26, ().

   Google Scholar

6. 6

   Tindal, J. S. (personal communication, ).

7. 7

   Issekutz, B., and Szende, J., Biochem. Z., , ().

   Google Scholar

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Affiliations

1. Department of Zoology, University of Liverpool

   C. L. SMITH

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SMITH, C. Action of Insulin on the Frog (Rana temporaria). Nature, – (). diseinuak4web.net

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